Building IP: BMY Patent Application Re “NTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AN

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Users should be sure to intentionally visit secure versions of sites. It is absolutely majestic to scroll through these endless options of submissive rainbow awards that seem to belong to pornographic sites. 65. The fusion protein of any one of claims 1 to 64, wherein the fusion protein further comprises a heterologous moiety fused to the first polypeptide and/or the second polypeptide. 12. The fusion protein of claim 10, wherein the second polypeptide is SEQ ID NO:12. 58. The fusion protein of claim 57, wherein the deletion is at amino acid A1. 13. The fusion protein of any one of claims 6 to 9, wherein the mutation is one or more substitutions of an amino acid that is glycosylated with an amino acid that is not glycosylated. 46. The fusion protein of claim 45, wherein the mutation is one or more substitutions of an amino acid that is glycosylated with an amino acid that is not glycosylated. 24. The fusion protein of any one of claims 15 to 23, wherein one of the substitutions is amino acid T85.

28. The fusion protein of any one of claims 15 to 27, wherein one of the substitutions is amino acid T203. 43. The fusion protein of any one of claims 34 to 42, wherein one of the substitutions is amino acid C192. 59. The fusion protein of any one of claims 1 to 58, wherein the fusion protein is deglycosylated enzymatically or chemically. 72. The fusion protein of any one of claims 1 to 71, which is a monomer. 30. The fusion protein of any one of claims 15 to 29, wherein one of the substitutions is amino acid T208. 32. The fusion protein of any one of claims 15 to 31, wherein one of the substitutions is amino acid T216. 2. The fusion protein of claim 1, wherein the extracellular domain of the IL2R.alpha. 6. The fusion protein of any one of claims 1 to 5, wherein the extracellular domain of the IL2R.alpha. 1. A fusion protein comprising: (a) a first polypeptide comprising an Interleukin-2 (IL2) polypeptide; and (b) a second polypeptide comprising an extracellular domain of an Interleukin-2 Receptor alpha (IL2R.alpha.) polypeptide; wherein (i) the extracellular domain of the IL2R.alpha.

11. The fusion protein of claim 10, wherein the second polypeptide is SEQ ID NO:11. 90. A method of producing the fusion protein of any one of claims 1 to 78, comprising: culturing the host cell of any one of claims 82 to 87 under suitable conditions and recovering the fusion protein. 94. The method of claim 93, wherein the host cell is a bacterial cell. 102. The method of claim 101, wherein the infectious disease is caused by a pathogenic virus. 104. The method of claim 101, wherein the infectious disease is caused by pathogenic bacteria. 108. The method of claim 101, wherein the infectious disease is caused by pathogenic parasite. 99. The method of claim 96, wherein the disease or disorder is an inflammatory disease or an autoimmune disease. 101. The method of claim 96, wherein the disease or disorder is an infectious disease. 113. The method of any one of claims 110 to 112, wherein the second agent is a cytokine inhibitor.

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